- te weinig serotonine geeft obstipatie
- teveel serotonine geeft diarrhee
- angst met diepe triestheid
- verhoogde pijngevoeligheid
- niet lekker in je vel zitten
= essentieel aminozuur, zit in melk, vlees en chocolade
- L-tryptofaan: lichaam kan het omzetten naar believen en wat het nodig heeft
- 5 hydroxitryptofaan: kan alleen omgezet worden in serotonine en geeft soms bijwerkingen
Supplement: SAMe butaandisulfonaat= lichaamseigen stof
= even effectief als antidepressivum (SSRI)
Vooraleer je aan de slag gaat met SAMe, lees deze link eerst:
A quick way to test for need for methylation therapy is to carry out a cautious trial of SAMe. Within a week or two you should have your answer. If she clearly is improving on the SAMs (which is frightfully expensive)..... you can get usually the same benefits (albeit more slowly) using methionine plus calcium, magnesium, and B-6. This should be side-effect free unless (a) the methylation is begun too abruptly or (b) the patient has a rare genetic enzyme disorder which disrupts the SAM cycle. We've found that direct methylation is usually more successful than tinkering with the SAM cycle. The primary way humans receive most of their methyl groups is from dietary methionine. It's often hard to improve on Mother Nature. (Jan 20, 2003)
SAMe is likely to cause great worsening of symptoms, including mania, if given to an OVER-methylated person. The incidence of overmethylation in our patient database of 1,500 bipolar cases is about 18%. Bipolar disorder is not a single condition, but a collection of very different biochemical disorders under the same umbrella diagnosis. SAMe works great for truly undermethylated patients, but all hell breaks out if given to someone who is overloaded (genetically) with methyl groups. The right way to do this is to (a) first determine the person's innate methylation tendency & then (b) act accordingly. (Jan 31, 2003)
Multiple food & chemical sensitivities are also associated with histapenia (low histamine, overmethylation), the largest of all SZ groups, amounting to about 48% of all cases. For this group, SZ symptoms often worsen if exposed to the offending substances, & nice improvements often occur if they are identified & avoided. However, the food sensitivities usually disappear after about 1 year of aggressive Folate/B-12/B-3 treatment, which is the primary route to a normal life for these patients.
Histamine assays for depression were introduced by Dr. Carl Pfeiffer of Princeton, NJ in the 1970' and 1980's. My clinic has found whole blood histamine to be very useful & has used this assay more than 30,000 times.
First of all, the analysis must be done for whole blood (not plasma, serum, etc), strictly adhering to the sampling protocol. We presently use LabCorp but in the past Quest also had proficiency for this assay.
The reference "normal" range for mental health is 40 to 70 ng/dL. Levels above 70 indicate undermethylation, whereas levels below 40 suggest overmethylation.
Undermethylated depressives thrive on l-methionine, calcium, magnesium, B-6, Zinc, and Vitamin C. In severe cases, up to 3,000 mg/day of methionine and 2,000 mg/day of Ca may be needed. However, we also like to routinely run a homocysteine test to assure the safety of the methylation protocol. This population is believed to result in low serotonin activity. This methylation therapy is quite slow in taking effect.... and often 6-8 weeks pass before progress is obvious.
Overmethylated (low-histamine) depressives thrive on folic acid, B-12, niacin (or niacinamide), B-6, Zinc, Manganese, DMAE, and Vitamins, C and E. In severe cases, up to 5,000 mcg/day of FA may be needed. Response is more rapid with this phenotype, with clear progress usually by week 4. This population is believed to have an innate tendency for elevated serotonin, dopamine, and norepinephrine levels.
This test can also help guide psychiatrists in selection of psychiatric medications. For example high histamine persons may do quite well on SSRI's, but low-histamine persons usually reactly very badly to SSRI's and are better candidates for benzodiazapines.
We like to augment the histamine blood test with an "absolute basophil" test offered by Direct Healthcare, Inc. The histamine assay can be affected by antihistamines and other medications with AH properties. The reference range for ABC's is 30-50.