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zaterdag 14 mei 2011

XMRV Symposium, June 9, 2011

XMRV Symposium

XMRV, a novel retrovirus is here to stay

When: June 9th - Faculteit geneeskunde en farmacie

Place to be: Vrije Universiteit Brussel - Laarbeeklaan 103 - 1090 Brussel - Belgium

Time: 4 pm - 7 pm


Admission: free

Programme to be announced next week


Judy A. Mikovits PhD (W.P.I., University of Nevada, U.S.A.)
XMRV and other gammaretroviruses (HGRVs) in neuro-immune diseases

Maureen Hanson PhD (Cornell University, U.S.A.)
Assays for MLV-like virus sequences in a New York CFS cohort

Cecilia Cabrera PhD (Irsi Caixa Foundation, Badalona, Spain)
Infection of Xenotropic Murine Leukemia Virus-related virus in human lymphoid tissue

Kenny De Meirleir M.D., PhD (Vrije Universiteit Brussel)
Prevalence of XMRV in CFS/ME and in healthy blood donors

Please note also in your agenda:

The 15th International Conference on Human Retroviruses: HTLV and Related Viruses will be held in Leuven, Belgium, June 5-8, 2011.

XMRV-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature

Source: In Vivo, 25:307-314, 2011

By Vincent C Lombardi, Judith A Mikovits, et al.


Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.

Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.

Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.

Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.

Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.

Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA.
[Email Dr. Vincent C Lobardi, WPI, U of Nevada –]