XMRV Symposium
XMRV, a novel retrovirus is here to stay
When: June 9th - Faculteit geneeskunde en farmacie
Place to be: Vrije Universiteit Brussel - Laarbeeklaan 103 - 1090 Brussel - Belgium
Time: 4 pm - 7 pm
Info: MarleenVL@ehmb.be
Admission: free
Programme to be announced next week
Presenters:
•Judy A. Mikovits PhD (W.P.I., University of Nevada, U.S.A.)
XMRV and other gammaretroviruses (HGRVs) in neuro-immune diseases
•Maureen Hanson PhD (Cornell University, U.S.A.)
Assays for MLV-like virus sequences in a New York CFS cohort
•Cecilia Cabrera PhD (Irsi Caixa Foundation, Badalona, Spain)
Infection of Xenotropic Murine Leukemia Virus-related virus in human lymphoid tissue
•Kenny De Meirleir M.D., PhD (Vrije Universiteit Brussel)
Prevalence of XMRV in CFS/ME and in healthy blood donors
Please note also in your agenda:
The 15th International Conference on Human Retroviruses: HTLV and Related Viruses will be held in Leuven, Belgium, June 5-8, 2011.
zaterdag 14 mei 2011
XMRV-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature
http://merutt.files.wordpress.com/2011/05/mikovits_lombardi-publikasjon-mai2001.pdf
Source: In Vivo, 25:307-314, 2011
By Vincent C Lombardi, Judith A Mikovits, et al.
Abstract
Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.
Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.
Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.
Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.
Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.
Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA.
[Email Dr. Vincent C Lobardi, WPI, U of Nevada – vclombardi@gmail.com]
Source: In Vivo, 25:307-314, 2011
By Vincent C Lombardi, Judith A Mikovits, et al.
Abstract
Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.
Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.
Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.
Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.
Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.
Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA.
[Email Dr. Vincent C Lobardi, WPI, U of Nevada – vclombardi@gmail.com]
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