Have you ever wondered why never catch a cold anymore since you have ME or CFS?
Maybe you suffer from mold intoxication. Some people simply cannot eliminate the neurotoxines released by mold. Some bacteria like Lyme, bartonella and babesia produce the same symptoms. Blue green algue, ciguaterae, chlamydia pneumonia, ... yessss same effect.
Sick building syndrome is not a new concept but a severely underestimated factor in ME. Why do doctors don't ever ask you if you have a leaky roof at your work or house, have musty tiles in the bathroom, HVAC at work, did you work as an airhostess, ... Maybe it is like opening a jar of worms because fixing mold is very expensive.
If it is at your work, change! If it is your house, move! If none of it is possible, think about it again!
Never ever try to remove the mold yourself. Never! You can die from it. Period. Google a professional. Check with your insurance company what can be done.
Minagawa K, Kouzuki S, Yoshimoto J, Kawamura Y, Tani H, Iwata T, Terui
Y, Nakai H, Yagi S, Hattori N, Fujiwara T, Kamigauchi T. Stachyflin and
acetylstachyflin,
novel anti-influenza A virus substances, produced by
Stachybotrys (black mold) sp. RF-7260. I. Isolation, structure elucidation and
biological activities. J Antibiot (Tokyo). 2002 Feb;55(2):155-64. PMID:
12002997
Two novel compounds, stachyflin and acetylstachyflin, have been isolated
by solid-state fermentation of Stachybotrys sp. RF-7260.
Stachyflin showed antiviral activity against influenza A virus (H1N1) in
vitro with an IC50 value of 0.003 microM. Acetylstachyflin was about
77-fold less active than stachyflin.
*
Mari Nakatani, Masahiko Nakamura, Akiyuki Suzuki, Munenori Inoue, and
Tadashi Katoh. A New Strategy toward the Total Synthesis of Stachyflin,
A
Potent Anti-Influenza A Virus Agent: Concise Route to the Tetracyclic
Core Structure. Org. Lett., 2002, 4 (25), pp 44834486. PMID: 12465918
A new strategy directed toward the total synthesis of stachyflin, a
potent and novel anti-influenza A virus agent isolated from a
microorganism, has been presented through the enantioselective synthesis
of the tetracyclic core structure. The synthetic method features a
BF3Et2O-induced domino epoxide-opening/rearrangement/cyclization
reaction as the key step.
*
Minagawa K, Kouzuki S, Tani H, Ishii K, Tanimoto T, Terui Y, Kamigauchi
T..
Novel stachyflin derivatives from Stachybotrys sp. RF-7260.
Fermentation, isolation, structure elucidation and biological
activities. J Antibiot (Tokyo). 2002 Mar;55(3):239-48. PMID: 12014438
Stachybotrys sp. RF-7260 was found to produce stachyflins, novel
anti-influenza virus agents, under solid-state fermentation conditions.
Feeding DL-lysine to a culture of Stachybotrys sp. RF-7260 induced the
formation of the novel compounds, SQ-02-S-L2 and -L1, and feeding
DL-valine the formation of SQ-02-S-VI and -V2. The structures of these
metabolites were determined by detailed 2D NMR analyses in comparison
with acetylstachyflin. SQ-02-S-L2 and -L1 have the lysine moiety and
SQ-02-S-V1 has the valine moiety. SQ-02-S-V2 has an amidine moiety
instead of the lactam moiety in acetylstachyflin. SQ-02-S-L2, -L1 and
-V1, substituted on the lactam amide hydrogen, displayed only a low
level of the antiviral activity. However, deacetyl SQ-02-S-V2 showed
potent antiviral activity similar to stachyflin.
*
Tani N, Dohi Y, Onji Y, Yonemasu K.
Antiviral activity of trichothecene
mycotoxins (deoxynivalenol, fusarenon-X, and nivalenol) against herpes
simplex virus types 1 and 2. Microbiol Immunol. 1995;39(8):635-7. PMID:
7494505
The effect of trichothecene mycotoxins, deoxynivalenol (DON),
fusarenon-X (FX) and nivalenol (NIV), on plaque formation of herpes
simplex virus types 1 and 2 (HSV-1 and HSV-2) in HEp-2 cells was
examined.
The 50% effective concentrations (EC50) of DON, FX, and NIV for HSV-1
plaque formation were 160, 56, and 120 ng/ml, respectively. Those for
HSV-2 plaque formation were 94, 26, and 50 ng/ml, respectively. These
three mycotoxins showed about 2-fold higher selectivity to HSV-2 than to
HSV-1. Plaque formation of HSV-1 was not inhibited with trichothecenes
at concentrations completely inhibiting plaque formation when cells were
treated during virus adsorption period or 15 hr before infection.
These results indicate that trichothecenes affect replication of HSV-1
after virus adsorption, but not before or during virus adsorption to the
host cells.
*
Sawadjoon S, Kittakoop P, Isaka M, Kirtikara K, Madla S, Thebtaranonth
Y.
Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the
fungus Stachybotrys nephrospora. Planta Med. 2004 Nov;70(11):1085-7.
PMID: 15549667
Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a
mycelium extract of the fungus Stachybotrys nephrospora BCC 3900.
Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral
activity (the IC50 value of 4.32 microg/mL) comparable to the standard
drug, acyclovir, while compound 2 was inactive against the HSV-1 virus.
Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and
0.15 microg/mL for 1 and 2, respectively), and were not toxic towards
the Vero cell line. A regiospecific conversion of the dialdehyde 1 to
the lactone 2 proceeded simply under acidic conditions.
© ap.
