http://www.patrikpeters.amalgaam.be/symptomen_kwikvergiftiging.htm
Extract:
Het zweet breekt over heel het lichaam uit. Het is te vergelijken met hoge koorts, met dit verschil dat de lichaamstemperatuur normaal blijft. Men heeft het dus niet te warm of te koud. Het vele zweet kan natuurlijk wel een afkoelend effect hebben.
Mensen welke neiging hebben tot tandenknarsen, doen dit vooral 's nachts tijdens hun slaap. Dit is in vele gevallen als gevolg van stress. In dat geval zullen ze dan ook vooral 's nachts last hebben van het zweten. Dit begint dan doorgaans een paar uur na het inslapen en kan nog de hele nacht verder duren. Binnen de kortste keren is de kleding, de lakens en het hoofdkussen helemaal doorweekt. Sommige mensen gebruiken dan badlakens om tussen te slapen. Deze moeten ze dan verscheidene malen per nacht vervangen. Het zweet laat doorgaans bruin-roze plekken achter op het ondergoed. Die plekken zijn dikwijls moeilijk uit te wassen.
zondag 29 januari 2012
Acetaminophen depletes glutathion
Acetaminophen = paracetamol
http://www.rjsharpe.com/acetaminophen/hypothesis.shtml
Acetaminophen: The Case for a Link to Neurodegenerative Diseases
Acetaminophen either decreases or depletes the endogenous anti-oxidant glutathione in mammalian cells. Without the protective effects of glutathione, mammalian cell damage or cell death occurs. Neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease and disorders of retinal cells, such as age associated macular degeneration, are due at least in part to cellular damage induced by free radicals and oxidative stress. By reducing or depleting neuronal and retinal glutathione, acetaminophen might trigger, accelerate or otherwise worsen these diseases.
Presentation of the Hypothesis
Although acetaminophen lacks the gastric toxicity and anti-platelet activity of aspirin and other classic NSAIDs, it is well known to have hepatotoxicity [7]. Chronic long term acetaminophen use increases the risk of liver failure and acute overdosage can cause fulminant liver necrosis and failure [7]. The mechanism by which acetaminophen causes liver toxicity is probably due to depletion of glutathione by this drug [7]. The hepatic cells are then unable to neutralize the toxic effects of peroxides, superoxide species and free radicals which are generated during the normal course of metabolism.
Neurons within the CNS are very metabolically active, moreover, there is evidence that the glutathione levels within CNS neurons fall with advancing age [8-10]. Others have postulated a role for oxidative stress in neurodegenerative diseases, including Parkinson’s’ disease and Alzheimer’s disease [8, 9].
Given the ability of acetaminophen to cross the blood-brain barrier and its glutathione reducing activity, I postulate that the use of acetaminophen amplifies the toxic effects of oxidative stress on CNS neurons as well as retinal cells and their neuronal network. Further, I hypothesize that the reduction of glutathione levels due to natural aging causes increased sensitivity to the toxic effects of acetaminophen in the elderly. Acetaminophen may thus be a direct cause of neurodegenerative and oculodegenerative diseases of the retina or may be a co-factor in the development and the acceleration of neuronal damage and loss in these diseases.
http://www.rjsharpe.com/acetaminophen/hypothesis.shtml
In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications).
http://emedicine.medscape.com/article/169814-overview
http://www.rjsharpe.com/acetaminophen/hypothesis.shtml
Acetaminophen: The Case for a Link to Neurodegenerative Diseases
Acetaminophen either decreases or depletes the endogenous anti-oxidant glutathione in mammalian cells. Without the protective effects of glutathione, mammalian cell damage or cell death occurs. Neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease and disorders of retinal cells, such as age associated macular degeneration, are due at least in part to cellular damage induced by free radicals and oxidative stress. By reducing or depleting neuronal and retinal glutathione, acetaminophen might trigger, accelerate or otherwise worsen these diseases.
Presentation of the Hypothesis
Although acetaminophen lacks the gastric toxicity and anti-platelet activity of aspirin and other classic NSAIDs, it is well known to have hepatotoxicity [7]. Chronic long term acetaminophen use increases the risk of liver failure and acute overdosage can cause fulminant liver necrosis and failure [7]. The mechanism by which acetaminophen causes liver toxicity is probably due to depletion of glutathione by this drug [7]. The hepatic cells are then unable to neutralize the toxic effects of peroxides, superoxide species and free radicals which are generated during the normal course of metabolism.
Neurons within the CNS are very metabolically active, moreover, there is evidence that the glutathione levels within CNS neurons fall with advancing age [8-10]. Others have postulated a role for oxidative stress in neurodegenerative diseases, including Parkinson’s’ disease and Alzheimer’s disease [8, 9].
Given the ability of acetaminophen to cross the blood-brain barrier and its glutathione reducing activity, I postulate that the use of acetaminophen amplifies the toxic effects of oxidative stress on CNS neurons as well as retinal cells and their neuronal network. Further, I hypothesize that the reduction of glutathione levels due to natural aging causes increased sensitivity to the toxic effects of acetaminophen in the elderly. Acetaminophen may thus be a direct cause of neurodegenerative and oculodegenerative diseases of the retina or may be a co-factor in the development and the acceleration of neuronal damage and loss in these diseases.
http://www.rjsharpe.com/acetaminophen/hypothesis.shtml
In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications).
http://emedicine.medscape.com/article/169814-overview
Antidepressants increase death rate 1,6 times
http://www.gaia-health.com/articles451/000458-antidepressants-increase-death-rate.shtml
Antidepressants Increase Death Rate: Non-Pharma Funded Research
Huge numbers of older men are dying from the use of antidepressants. A PLoS ONE study documents the extent of the carnage.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011266
by Heidi Stevenson
18 May 2011
A shocking study that should have received serious attention from the press and doctors seems to have been ignored. It documents that the death rate of depressed people who take antidepressants is, on average, 1.6 times greater than those who don't take them.
The respected journal, PLoS ONE, published the study in June 2010. It will come as no surprise that there was no pharmaceutical money funding the study. Performed in Australia, the study followed 5,276 men aged 68-88. The claim that depression is a deadly disease is true. The death rate of those diagnosed as depressed is significantly greater than others, and that mortality increases with increasing severity. Those points were the authors' focus. However, the study also shows that the men who are depressed and take trycyclic, SSRI, or any other antidepressants die at a significantly greater rate than those who don't.
The Figures for Increased Death with Antidepressants
One of the saddest things about the study is that the authors didn't dare tell the entire truth in their conclusion. Rather than point out that the death rate is 1.6 times higher for depressed men taking antidepressants, they simply stated:
The use of antidepressants does not reduce the mortality rates of older men with persistent symptoms of depression.
Technically, that's true—but it is, in effect, a lie. The reality is that antidepressants are clearly causing deaths in older men. Here is the graph they produced that documents the increased risk of death for each type of antidepressant compared with the death rate of undrugged patients:
(I have added legends to make it easy to see the results at a glance.)
he graph is based on hazard ratios, which are the increased rates of death. For example, a hazard ratio of 2 would refer to a doubled risk of death. Each of the bars shows the increased rate of death for the men taking a particular type of antidepressant. Here is a table of the results shown above:
You'll notice that the morbiditiy risk ratio figures for the types of antidepressants is specified as approximate. That's because the authors didn't present figures for those, so I estimated them from the graph.
Though the authors did present the specific risk ratios for causes of death, they avoided presenting the figures for increased morbidity for each type of antidepressant. While the reasons for death are certainly interesting, it should be obvious that the most important issue is simply whether and how much a drug increases the risk.
One of the primary reasons used to push antidepressants is that depression is a deadly disease. It sounds good, and this study shows that it's true. However, the implication that taking drugs saves lives is nothing short of a lie. And this particular lie is obviously killing people—yet not a single one of them is counted among the numbers who die from pharmaceutical drugs, nor are they counted as iatrogenic injuries.
Causes of Death
Now, let's take a look at how older men die. The tale becomes even murkier. The study revealed that the rate of suicides and accidents goes up in only one group: men with no depression who are given antidepressants. While the increase is small, it's certainly interesting.
The most significant causes of increased morbidity with antidepressants were cardiovascular diseases and cancer. Each of these nearly doubled with antidepressant use in depressed men over those who were depressed but did not take antidepressants. In men who were not depressed, there was little change. Deaths from infections nearly doubled, too.
This study is not definitive, with the most important factor being that it focused only on men over age 68. Nonetheless, the following conclusions should have been made:
•Men over age 68 should never take antidepressants.
•The claim that one should take antidepressants because depression is a deadly disease is obviously based on nothing.
•People of any age should question taking antidepressants. If they result in hugely increased death rates in older men, why should anyone assume that the story is different in women or younger people?
As documented in Gaia Health, antidepressants have been shown to cause increases in miscarriages, deformities in the babies of women who take them during pregnancy, and violence.
http://www.cbc.ca/news/canada/british-columbia/story/2011/09/19/bc-depressionbabies.html
This study, along with others for men and women of all ages—not to mention children!—should have been done years ago. The reason they haven't been done is inadvertently demonstrated by the fact that the authors assiduously avoided expressing the most startling results of their study: that antidepressants are clearly causing the deaths of thousands, possibly millions, of people.
Even when there was no Big Pharma money funding the study, the authors apparently feared to tell the truth about their findings. Instead, they hid the results behind dissembling words, words designed to give a false impression. Their data clearly shows that antidepressants are killing older men, and doing so at incredibly high numbers. Yet, they didn't utter a word of that in their conclusion. That demonstrates the fear that even honest researchers must be facing when their results show something that Big Pharma and Big Medicine would prefer not be revealed.
Sources:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011266
http://www.gaia-health.com/articles451/000458-antidepressants-increase-death-rate.shtml
http://www.cbc.ca/news/canada/british-columbia/story/2011/09/19/bc-depressionbabies.html
Antidepressants Increase Death Rate: Non-Pharma Funded Research
Huge numbers of older men are dying from the use of antidepressants. A PLoS ONE study documents the extent of the carnage.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011266
by Heidi Stevenson
18 May 2011
A shocking study that should have received serious attention from the press and doctors seems to have been ignored. It documents that the death rate of depressed people who take antidepressants is, on average, 1.6 times greater than those who don't take them.
The respected journal, PLoS ONE, published the study in June 2010. It will come as no surprise that there was no pharmaceutical money funding the study. Performed in Australia, the study followed 5,276 men aged 68-88. The claim that depression is a deadly disease is true. The death rate of those diagnosed as depressed is significantly greater than others, and that mortality increases with increasing severity. Those points were the authors' focus. However, the study also shows that the men who are depressed and take trycyclic, SSRI, or any other antidepressants die at a significantly greater rate than those who don't.
The Figures for Increased Death with Antidepressants
One of the saddest things about the study is that the authors didn't dare tell the entire truth in their conclusion. Rather than point out that the death rate is 1.6 times higher for depressed men taking antidepressants, they simply stated:
The use of antidepressants does not reduce the mortality rates of older men with persistent symptoms of depression.
Technically, that's true—but it is, in effect, a lie. The reality is that antidepressants are clearly causing deaths in older men. Here is the graph they produced that documents the increased risk of death for each type of antidepressant compared with the death rate of undrugged patients:
(I have added legends to make it easy to see the results at a glance.)
he graph is based on hazard ratios, which are the increased rates of death. For example, a hazard ratio of 2 would refer to a doubled risk of death. Each of the bars shows the increased rate of death for the men taking a particular type of antidepressant. Here is a table of the results shown above:
You'll notice that the morbiditiy risk ratio figures for the types of antidepressants is specified as approximate. That's because the authors didn't present figures for those, so I estimated them from the graph.
Though the authors did present the specific risk ratios for causes of death, they avoided presenting the figures for increased morbidity for each type of antidepressant. While the reasons for death are certainly interesting, it should be obvious that the most important issue is simply whether and how much a drug increases the risk.
One of the primary reasons used to push antidepressants is that depression is a deadly disease. It sounds good, and this study shows that it's true. However, the implication that taking drugs saves lives is nothing short of a lie. And this particular lie is obviously killing people—yet not a single one of them is counted among the numbers who die from pharmaceutical drugs, nor are they counted as iatrogenic injuries.
Causes of Death
Now, let's take a look at how older men die. The tale becomes even murkier. The study revealed that the rate of suicides and accidents goes up in only one group: men with no depression who are given antidepressants. While the increase is small, it's certainly interesting.
The most significant causes of increased morbidity with antidepressants were cardiovascular diseases and cancer. Each of these nearly doubled with antidepressant use in depressed men over those who were depressed but did not take antidepressants. In men who were not depressed, there was little change. Deaths from infections nearly doubled, too.
This study is not definitive, with the most important factor being that it focused only on men over age 68. Nonetheless, the following conclusions should have been made:
•Men over age 68 should never take antidepressants.
•The claim that one should take antidepressants because depression is a deadly disease is obviously based on nothing.
•People of any age should question taking antidepressants. If they result in hugely increased death rates in older men, why should anyone assume that the story is different in women or younger people?
As documented in Gaia Health, antidepressants have been shown to cause increases in miscarriages, deformities in the babies of women who take them during pregnancy, and violence.
http://www.cbc.ca/news/canada/british-columbia/story/2011/09/19/bc-depressionbabies.html
This study, along with others for men and women of all ages—not to mention children!—should have been done years ago. The reason they haven't been done is inadvertently demonstrated by the fact that the authors assiduously avoided expressing the most startling results of their study: that antidepressants are clearly causing the deaths of thousands, possibly millions, of people.
Even when there was no Big Pharma money funding the study, the authors apparently feared to tell the truth about their findings. Instead, they hid the results behind dissembling words, words designed to give a false impression. Their data clearly shows that antidepressants are killing older men, and doing so at incredibly high numbers. Yet, they didn't utter a word of that in their conclusion. That demonstrates the fear that even honest researchers must be facing when their results show something that Big Pharma and Big Medicine would prefer not be revealed.
Sources:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011266
http://www.gaia-health.com/articles451/000458-antidepressants-increase-death-rate.shtml
http://www.cbc.ca/news/canada/british-columbia/story/2011/09/19/bc-depressionbabies.html
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