zondag 25 december 2011
vrijdag 23 december 2011
Glutathione levels in health and sickness
http://www.ncbi.nlm.nih.gov/pubmed/11271724
It is very difficult to absorb glutathion via supplements (except IV) but you can raise its level with 8% just by consuming 2 brazil nuts a day. They are very high in natural selenium and this is necessary for the production of glutathion.
"As the integrity of the cellular and subcellular membranes depends heavily on glutathione peroxidase, the antioxidative protective system of glutathione peroxidase itself depends heavily on the presence of selenium."
Brazil nuts look like this:
Indian J Med Sci. 2000 Feb;54(2):52-4.
Glutathione levels in health and sickness.
Source
Departments of Biochemistry and Medicine, Pandit BD, Sharma PGIMS, Rohtak.Abstract
We speculate that the glutathione (GSH) status of human subjects could be an indicator of health and functional age. In this regard, in a study in which, 80 young and 40 elderly healthy individuals were selected as control. We also studied 145 patients with chronic illnesses namely, ischaemic heart disease, diabetes, preeclampsia, cataract, chronic renal failure and leukaemia (age 52 +/- 8.6 years). We observed that all the subjects had high malonadildehyde and low glutathione levels as compared to control. These early observations support the hypothesis that oxidative stress may have an important aetiological rule and antioxidants a potential therapeutic role.It is very difficult to absorb glutathion via supplements (except IV) but you can raise its level with 8% just by consuming 2 brazil nuts a day. They are very high in natural selenium and this is necessary for the production of glutathion.
"As the integrity of the cellular and subcellular membranes depends heavily on glutathione peroxidase, the antioxidative protective system of glutathione peroxidase itself depends heavily on the presence of selenium."
Brazil nuts look like this:
donderdag 22 december 2011
Unexpected cardiac symptoms with cytomegalovirus CMV infection
Rowe and colleagues [11] described seven nonsyncopal adolescents presenting with fatigue an lightheadedness and demonstrated abnormal responses to upright tilt. They followed this work with a prospective, nonselected, nonblinded study confirming a strong association between neurally mediated hypotention and CFS [12]. An abnormal response to upright tilt was observed in 22 of 23 patients with CFS vs. four of 14 controls (P<.001). Open, nonblinded therapy directed at this abnormal reflex with fludrocortisone, B-adreniergic blocking agents and disopyramide appeared beneficial in this nonblinded trial. The authors concluded that neurally mediated hypotension is a cause of the symptoms of CFS or that it is strongly associated with another important etiologic factor.
We reported in 1993 that repetitively oscillating abnormal T-waves inversions and/or T-wave flats during 24-hour electrocardiogram (ECG) monitoring are present in patients with CFS, ECG abnormalities that are nonspecific but seen less frequently in non-CFs patients (P-<.01) [13]. Abnormal left ventricular myocardial dynamics are present in a cohort of patients with CFS. Decreased and /or flat ejection fractions with stress, , abnormal wall motion at rest and stress, dilatation of the left ventricle, and segmental wall motion abnormalities in CFS patients[14].
We now report a subset of CFS patients with (1) high human cytomegalovirus (HCMV) IgG enzyme-linked immunoassay antibody titers (ELISA), (2) minimal or no serologic evidence of concurrent EBV multiplication, and (3) oscillating ECG abnormalities at Holter monitoring. We performed a pilot study to assess the possible efficacy of ganciclovir, an antiviral nucleoside useful in the treatment of several HCMV infections in immunosuppressed patients.
... Mitral valve prolapse without significant mitral valve insufficiency does not cause abnormal T-wave oscillations at Holter monitoring [19]. As previously, 24-hour continuous ECGs were obtained using a mdified standard lead I and precordial lead V [13]. A patient's 24-h Holter monitor was considered flat, i.e., the T-waves were below the horizontal described by inceptions of p and Q waves in on the the two monitored lead with two or more episodes for at least 25.0 normally conducted QRS complexes. A uniformly flat T-wave were evaluated independent of possible ST segment changes. Biphasic T -wave were considered normal. U waves ( a small, shollow, positive, rounded delflection inscribed immediately after the T-wave) did not interfere with this analysis, Labile T- wave abnormalities at Holter monitoring were present in each CFS patient.
Validation of EI for the severity of the CFS:
Grade 0: Patients are confined to bed by number and severity of symptoms listed below.
Grades 1-2: Any activity leads to overwhelming, incapacitating fatigue. Patients are lightheaded, unable to think clearly, concentrate, or read for any extended period (over 60 minutes). Left-sided chest aches, palpitations, sore throats, and feverishness are frequent. Patients can be out of bed only for intermittent, brief parts of each day.
Grades 3-5: With great effort, patients can be out of bed and perform nonphysical activities for several hours each day. Any exertion markedly worsens fatigue. Patients variably express lightheadedness and inability to think clearly or read normally. Left-sided chest aches, palpitations, sore throats, and feverishness are frequent. Patients cannot perform a 40-hour a week sedentary job or maintain the duties of homemaker (e.g., cooking, cleaning, doing laundry, shopping, driving).
Grades 6-9: Patients can assume normal activities, maintain a 40-hour work week, and with pacing, maintain a household. Overwhelming fatigue is lessened. Rare-to-no lightheadedness, foggy thinking, chest aches, palpitations, feverishness, and sore throats are present. Patients can perform light physical work (or exercise) in moderation without fatigue.
Grade 10: Patients are well, with normal energy level, stamina, and sense of well-being. Exercise in moderation leads to an increased sense of well-being. Lightheadedness, difficulties in concentrating and reading ability, chest aches, palpitations, sore throats, and feverishness are absent.
Treatment:
After placement of a peripherally inserted central or Groshong catheter, ganciclovir (5 mg/kg q 12 h) was given intravenously for 30 days. ... After completion of ganciclovir, patients were encouraged to renew normal activities in gradual increments as tolerated. They were asked to not exercise until six months after completion of ganciclovir.
Results:
At the start of ganciclovir, the severity of fatigue (E1) in all patients was similar (e.g., 3, mean grade, group A vs. 2, mean grade, group B). Six months later, the energy indices diverged. Mean EIs were grade 7 and grade 4 for groups A and B, respectively (table 4). Before therapy with ganciclovir, n patient (group A or group B) could work or function normally (e.g., homemaker).
After treatment with ganciclovir, the 13 patients from group A, but no patient from group B, returned to his or her premorbid activity. A repeat measures analysis of the EI values between cohorts indicated that patients in group A had greater improvement than those in group B (P <.05).
Read the full report at:
http://www.ncf-net.org/library/ganciclovir.htm
We reported in 1993 that repetitively oscillating abnormal T-waves inversions and/or T-wave flats during 24-hour electrocardiogram (ECG) monitoring are present in patients with CFS, ECG abnormalities that are nonspecific but seen less frequently in non-CFs patients (P-<.01) [13]. Abnormal left ventricular myocardial dynamics are present in a cohort of patients with CFS. Decreased and /or flat ejection fractions with stress, , abnormal wall motion at rest and stress, dilatation of the left ventricle, and segmental wall motion abnormalities in CFS patients[14].
We now report a subset of CFS patients with (1) high human cytomegalovirus (HCMV) IgG enzyme-linked immunoassay antibody titers (ELISA), (2) minimal or no serologic evidence of concurrent EBV multiplication, and (3) oscillating ECG abnormalities at Holter monitoring. We performed a pilot study to assess the possible efficacy of ganciclovir, an antiviral nucleoside useful in the treatment of several HCMV infections in immunosuppressed patients.
... Mitral valve prolapse without significant mitral valve insufficiency does not cause abnormal T-wave oscillations at Holter monitoring [19]. As previously, 24-hour continuous ECGs were obtained using a mdified standard lead I and precordial lead V [13]. A patient's 24-h Holter monitor was considered flat, i.e., the T-waves were below the horizontal described by inceptions of p and Q waves in on the the two monitored lead with two or more episodes for at least 25.0 normally conducted QRS complexes. A uniformly flat T-wave were evaluated independent of possible ST segment changes. Biphasic T -wave were considered normal. U waves ( a small, shollow, positive, rounded delflection inscribed immediately after the T-wave) did not interfere with this analysis, Labile T- wave abnormalities at Holter monitoring were present in each CFS patient.
Validation of EI for the severity of the CFS:
Grade 0: Patients are confined to bed by number and severity of symptoms listed below.
Grades 1-2: Any activity leads to overwhelming, incapacitating fatigue. Patients are lightheaded, unable to think clearly, concentrate, or read for any extended period (over 60 minutes). Left-sided chest aches, palpitations, sore throats, and feverishness are frequent. Patients can be out of bed only for intermittent, brief parts of each day.
Grades 3-5: With great effort, patients can be out of bed and perform nonphysical activities for several hours each day. Any exertion markedly worsens fatigue. Patients variably express lightheadedness and inability to think clearly or read normally. Left-sided chest aches, palpitations, sore throats, and feverishness are frequent. Patients cannot perform a 40-hour a week sedentary job or maintain the duties of homemaker (e.g., cooking, cleaning, doing laundry, shopping, driving).
Grades 6-9: Patients can assume normal activities, maintain a 40-hour work week, and with pacing, maintain a household. Overwhelming fatigue is lessened. Rare-to-no lightheadedness, foggy thinking, chest aches, palpitations, feverishness, and sore throats are present. Patients can perform light physical work (or exercise) in moderation without fatigue.
Grade 10: Patients are well, with normal energy level, stamina, and sense of well-being. Exercise in moderation leads to an increased sense of well-being. Lightheadedness, difficulties in concentrating and reading ability, chest aches, palpitations, sore throats, and feverishness are absent.
Treatment:
After placement of a peripherally inserted central or Groshong catheter, ganciclovir (5 mg/kg q 12 h) was given intravenously for 30 days. ... After completion of ganciclovir, patients were encouraged to renew normal activities in gradual increments as tolerated. They were asked to not exercise until six months after completion of ganciclovir.
Results:
At the start of ganciclovir, the severity of fatigue (E1) in all patients was similar (e.g., 3, mean grade, group A vs. 2, mean grade, group B). Six months later, the energy indices diverged. Mean EIs were grade 7 and grade 4 for groups A and B, respectively (table 4). Before therapy with ganciclovir, n patient (group A or group B) could work or function normally (e.g., homemaker).
After treatment with ganciclovir, the 13 patients from group A, but no patient from group B, returned to his or her premorbid activity. A repeat measures analysis of the EI values between cohorts indicated that patients in group A had greater improvement than those in group B (P <.05).
Read the full report at:
http://www.ncf-net.org/library/ganciclovir.htm
How high are your Epstein Barr titers?
Uittreksel: Hoge titers van anti-VCA IgG en anti-EA IgG, kunnen indiatief zijn voor verhoogde EBV replicatie of reactivatie.
Extract: High titers of anti-VCA IgG and anti-EA IgG, can be indicative of increased EBV reactivation and replication.
Infectious causes for chronic fatigue
Do you have Epstein Barr (EBV), cytomagalovirus (CMV), HHV-6, mycoplasma, chlamydia pneumonia and/or borrelia burgdorferi (Lyme disease)?
Does your doctor say your blood doesn't show you have an active infection?
Maybe he is wrong! Recurrent infections don't trigger IgM antibodies because the infection is intracellular. A few weeks after the reactivation of the virus, the IgM antibodies will stop and be replaced by IgG. Most people have high IgG levels. Some people although have low IgG levels because of their dysfunctional immune system. The body is unable to protect itself.
PCR testing therefore is more appropriate in a research setting.
How does dr Lerner treat these patients? With antivirals mostly.
Let's say you have elevated IgG CMV titers :
a combination of oral Valtrex + intravenous ganciclovir = dramatic improvement
The document has more treatment protocols as well as references to studies.
Have a look at it and hand it over to your doctor. It may be the start of a new beginning!
http://www.holtorfmed.com/index.php?section=downloads&file_id=46
Does your doctor say your blood doesn't show you have an active infection?
Maybe he is wrong! Recurrent infections don't trigger IgM antibodies because the infection is intracellular. A few weeks after the reactivation of the virus, the IgM antibodies will stop and be replaced by IgG. Most people have high IgG levels. Some people although have low IgG levels because of their dysfunctional immune system. The body is unable to protect itself.
PCR testing therefore is more appropriate in a research setting.
How does dr Lerner treat these patients? With antivirals mostly.
Let's say you have elevated IgG CMV titers :
a combination of oral Valtrex + intravenous ganciclovir = dramatic improvement
The document has more treatment protocols as well as references to studies.
Have a look at it and hand it over to your doctor. It may be the start of a new beginning!
http://www.holtorfmed.com/index.php?section=downloads&file_id=46
maandag 28 november 2011
Common infectious drivers, how to correct them?
Rheumatoid arthritis => Parasites => Parastat, HCL, Galactan
Lupus => Virus of the kidneys and/or lungs => Allicidin, HM Nano
Crohn's disease => Parasites, Mycobacterium, Paratuberculosis => Parastat, Allicidin, Paracidin
Celiac sprue => Parasites => Parastat, Allicidin, Paracidin
Scleroderma => Mycoplasma => Parastat, Hyssop
Juvenile RA => Mycoplasma pneumonia => HM Nano Detox
Juveline Diabetes => Coxsackie B virus => Allicidin, HM Nano
Hashimoto's => Heavy metal toxicity => HM Nano Detox
Obsessive Compulsive disorder => Streptococcal bacteria => Allicidin
Lupus => Virus of the kidneys and/or lungs => Allicidin, HM Nano
Crohn's disease => Parasites, Mycobacterium, Paratuberculosis => Parastat, Allicidin, Paracidin
Celiac sprue => Parasites => Parastat, Allicidin, Paracidin
Scleroderma => Mycoplasma => Parastat, Hyssop
Juvenile RA => Mycoplasma pneumonia => HM Nano Detox
Juveline Diabetes => Coxsackie B virus => Allicidin, HM Nano
Hashimoto's => Heavy metal toxicity => HM Nano Detox
Obsessive Compulsive disorder => Streptococcal bacteria => Allicidin
Glutathion does miracles for Parkinson!
Parkinson kan behandeld worden met intraveneuze glutathion. Volgende maand komt het product uit op de markt. De resultaten zijn fantastisch. Na 30 minuten stopt het beven en kan de patient weer normaal praten.
It takes only 30 minutes with IV glutathion to stop shaking and be able to speak normal again!
http://www.youtube.com/watch?v=uQRCpdcGwIU
This medicine will be on the market beginning 2012.
Who is doctor Perlmutter?
Dr Perlmutter doet aan "functional medicine" ipv aan "conventional medicine".
http://www.youtube.com/watch?v=y_Yy1WfO9Ns&feature=related
Prevent people to be ill, allow them to be healthy. Doctors should have the confidence to help their patients because functional medicine is far more effective.
It takes only 30 minutes with IV glutathion to stop shaking and be able to speak normal again!
http://www.youtube.com/watch?v=uQRCpdcGwIU
This medicine will be on the market beginning 2012.
Who is doctor Perlmutter?
Dr Perlmutter doet aan "functional medicine" ipv aan "conventional medicine".
http://www.youtube.com/watch?v=y_Yy1WfO9Ns&feature=related
Prevent people to be ill, allow them to be healthy. Doctors should have the confidence to help their patients because functional medicine is far more effective.
dinsdag 22 november 2011
Why exercise is dangerous for ME patients
The more serious type of fatigue is the one resulting from excessive build-up of ROS in the muscle and depletion of ATP. This type of “fatigue” is extreme prostration that occurs 8 or more hours after exercise (or what passes for “exercise” in CFS/ME patients and would be considered normal activity by healthy people.) Patients feel a deep, whole-body weariness and feel the necessity to lie still and not move due to extreme fatigue. Trying to even turn over in bed requires a great deal of painful effort of will. In addition, patients feel very sore all over their bodies. CFS/ME patients often describe this as feeling being beaten up and run over by a Mack truck or bus. The term post-exertional “malaise” seems pathetically inadequate as a descriptor of this feeling.
Mitochondrial specialist Dr. Donald Johns has warned that when a patient feels this way, it is very important to listen to his/her body. The extreme fatigue feeling is from depletion of ATP and the beaten-up/run-over feeling is from excessive ROS that not only did permanent damage to muscle cells, but also is still doing damage. Thus, it is essential to stay in bed and move as little as possible until the condition improves—even if that takes days. The best thing to do is for the patient to try to avoid getting into this condition in the first place by pacing and staying inside his/her “energy envelope.” This is not so easy to do at times, however.
ROS produced in the mitochondria damage mitochondrial DNA, for instance.3 This leads to alterations to the polypeptides encoded by the DNA. A decrease in electron transfer then ensues, but electron transfer is needed for generation of ATP. Thus, more ROS are produced in a vicious circle of oxidative distress and energetic decline.52 Mitochondrial DNA damage also results in daughter cells that are mutated and in cellular apoptosis.4, 5, 6, 7, 28
Muscle inflammation and oxidative stress are now known to play an important role in muscle atrophy.53 In addition, many CFS/ME patients have a low-grade fever, which means they have high levels of interleukin-1 (IL-1).54, 55 IL-1 is known to cause muscle catabolism (muscle destruction).54, 55 So CFS/ME patients with high levels of ROS and low-grade fevers can expect noticeable destruction of skeletal muscle with difficulty in replacing it.
ROS generated from mitochondria also damages proteins and lipid in membrane components for mitochondria membranes and cellular membranes. This results in more mitochondrial dysfunction and cellular apoptosis.4, 5, 6, 7, 28
Source: http://www.masscfids.org/resource-library/13/302
Mitochondrial specialist Dr. Donald Johns has warned that when a patient feels this way, it is very important to listen to his/her body. The extreme fatigue feeling is from depletion of ATP and the beaten-up/run-over feeling is from excessive ROS that not only did permanent damage to muscle cells, but also is still doing damage. Thus, it is essential to stay in bed and move as little as possible until the condition improves—even if that takes days. The best thing to do is for the patient to try to avoid getting into this condition in the first place by pacing and staying inside his/her “energy envelope.” This is not so easy to do at times, however.
ROS produced in the mitochondria damage mitochondrial DNA, for instance.3 This leads to alterations to the polypeptides encoded by the DNA. A decrease in electron transfer then ensues, but electron transfer is needed for generation of ATP. Thus, more ROS are produced in a vicious circle of oxidative distress and energetic decline.52 Mitochondrial DNA damage also results in daughter cells that are mutated and in cellular apoptosis.4, 5, 6, 7, 28
Muscle inflammation and oxidative stress are now known to play an important role in muscle atrophy.53 In addition, many CFS/ME patients have a low-grade fever, which means they have high levels of interleukin-1 (IL-1).54, 55 IL-1 is known to cause muscle catabolism (muscle destruction).54, 55 So CFS/ME patients with high levels of ROS and low-grade fevers can expect noticeable destruction of skeletal muscle with difficulty in replacing it.
ROS generated from mitochondria also damages proteins and lipid in membrane components for mitochondria membranes and cellular membranes. This results in more mitochondrial dysfunction and cellular apoptosis.4, 5, 6, 7, 28
Source: http://www.masscfids.org/resource-library/13/302
maandag 21 november 2011
Growing new mitochondria, it's possible!
PQQ – Pyrroloquinoline Quinone
One of the most interesting mitochondrial nutrients is PQQ. This nutrient, being considered as a possible new vitamin, is both a potent antioxidant and one of the few substances shown to help grow new mitochondria. For a patient with long-term mitochondrial damage, helping to grow new mitochondria may be particularly important.
PQQ (Pyrroloquinoline Quinone — also known as methoxatin) is a potent antioxidant that offers several health benefits for the mitochondria found in every human cell. Mitochondria are the descendants of ancient bacteria that live inside of human cells and provide most of their power. Human cells typically contain from 2 to 2500 mitochondria per cell. Cells in high energy usage organs such as the heart, brain, kidney, and liver generally have the largest quantities of mitochondria.
Recent research demonstrates that PQQ helps grow new mitochondria essential to the energy supply in every human cell.
PQQ is synergistic with CoQ10 (ubiquinol) supplements. Those who are seeking the best results generally will get extra benefit out of combining PQQ with some form of CoQ10 supplement.
Source: http://emediahealth.com/supplements/pqq/
Related Articles
■Low Cortisol, Low CoQ10, and Mitochondrial Dysfunction Often Found in Adrenal Fatigue, Chronic Fatigue Syndrome, Fibromyalgia, and Myalgic Encephalomyelitis Patients
■Shilajit's DBP Claimed to Enhance CoQ10 Function Inside Mitochondria
■Free Webinar on Anti-Aging Supplements Including PQQ
■Vitamin-Like PQQ Offers Antioxidant, Neuroprotective, and Mitochondrial Health Benefits
One of the most interesting mitochondrial nutrients is PQQ. This nutrient, being considered as a possible new vitamin, is both a potent antioxidant and one of the few substances shown to help grow new mitochondria. For a patient with long-term mitochondrial damage, helping to grow new mitochondria may be particularly important.
PQQ (Pyrroloquinoline Quinone — also known as methoxatin) is a potent antioxidant that offers several health benefits for the mitochondria found in every human cell. Mitochondria are the descendants of ancient bacteria that live inside of human cells and provide most of their power. Human cells typically contain from 2 to 2500 mitochondria per cell. Cells in high energy usage organs such as the heart, brain, kidney, and liver generally have the largest quantities of mitochondria.
Recent research demonstrates that PQQ helps grow new mitochondria essential to the energy supply in every human cell.
PQQ is synergistic with CoQ10 (ubiquinol) supplements. Those who are seeking the best results generally will get extra benefit out of combining PQQ with some form of CoQ10 supplement.
Source: http://emediahealth.com/supplements/pqq/
Related Articles
■Low Cortisol, Low CoQ10, and Mitochondrial Dysfunction Often Found in Adrenal Fatigue, Chronic Fatigue Syndrome, Fibromyalgia, and Myalgic Encephalomyelitis Patients
■Shilajit's DBP Claimed to Enhance CoQ10 Function Inside Mitochondria
■Free Webinar on Anti-Aging Supplements Including PQQ
■Vitamin-Like PQQ Offers Antioxidant, Neuroprotective, and Mitochondrial Health Benefits
zondag 20 november 2011
Treatment plan for adrenal insuffiency
http://www.drlam.com/articles/adrenal_fatigue.asp?page=3
how to support with supplements
http://www.holtorfmed.com/dr-pdf/Diagnosis%20Treatment%20CFS%20FM.pdf
medical treatment
A nutritional program that does not address adrenal insufficiency issues may eventually fail. Physicians and other healthcare practitioners often misdiagnose adrenal insufficiency. In this article, we will discuss the signs, symptoms, etiologies, diagnosis, and posible treatments from both a conventional and complementary perspective.
Print out and hand over to your doctor :)
how to support with supplements
http://www.holtorfmed.com/dr-pdf/Diagnosis%20Treatment%20CFS%20FM.pdf
medical treatment
A nutritional program that does not address adrenal insufficiency issues may eventually fail. Physicians and other healthcare practitioners often misdiagnose adrenal insufficiency. In this article, we will discuss the signs, symptoms, etiologies, diagnosis, and posible treatments from both a conventional and complementary perspective.
Print out and hand over to your doctor :)
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